Bmi1 (1C1) Monoclonal Antibody
Product Specifications
Background
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
Synonyms
Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, RING finger protein 51, BMI1
Swiss Prot
P35226
Host
Rabbit
Cross Reactivity
Human, Rat
Target
Bmi1
Clonality
Monoclonal
Isotype
IgG
Clone
1C1
Conjugation
Unconjugated
Source
C terminal Human Bmi1
Applications
WB, IHC-P, IF (ICC), IHC
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), IHC-P (1:200-400), IF (ICC) (1:50-200), IHC ()
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
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