SMC1 (Ser957) (8H5) Monoclonal Antibody
Product Specifications
Background
Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
Synonyms
Structural maintenance of chromosomes protein 1A, Sb1.8, Structural maintenance of chromosomes protein 1B, SMC protein 1A, SMC-1-alpha, SMC-1A, SMC1A, SMC protein 1B, SMC-1-beta, SMC-1B, SMC1B
Gene ID
8243
Swiss Prot
Q14683
Modification Site
Ser957
Host
Rabbit
Cross Reactivity
Human
Target
SMC1 (Ser957)
Clonality
Monoclonal
Isotype
IgG
Clone
8H5
Conjugation
Unconjugated
Source
Synthetic phospho-peptide corresponding to residues surrounding Ser957 of human SMC1
Applications
WB, IHC-P, IF (ICC), IHC
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), IHC-P (1:200-400), IF (ICC) (1:50-200), IHC ()
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
8243
Curated Selection
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