GRK2 (42D1) Monoclonal Antibody
Product Specifications
Background
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378) . Positively regulates ciliary smoothened (SMO) -dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity) .
Synonyms
Beta-adrenergic receptor kinase 1, G-protein coupled receptor kinase 2, Beta-ARK-1, ADRBK1, BARK, BARK1, GRK2
Gene ID
156
Swiss Prot
P25098
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
GRK2
Clonality
Monoclonal
Isotype
IgG
Clone
42D1
Conjugation
Unconjugated
Source
Recombinant Human GRK2 between 470 to 700 amino acids
Applications
WB, IHC-P, IF (ICC), IHC
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), IHC-P (1:200-400), IF (ICC) (1:50-200), IHC ()
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
156
Curated Selection
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