Caspase-9 (2A7) Monoclonal Antibody
Product Specifications
Background
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly (ADP-ribose) polymerase (PARP) . Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
Synonyms
Caspase-9; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; ICE-like apoptotic protease 6; CASP-9; APAF-3; ICE-LAP6; CASP9
Gene ID
842
Swiss Prot
P55211
Cellular Locus
Mitochondrion
Host
Rabbit
Cross Reactivity
Human, Mouse
Target
CASP9
Clonality
Monoclonal
Isotype
IgG
Clone
2A7
Conjugation
Unconjugated
Source
Recombinant human Caspase-9 between 200 to 350 amino acids
Applications
WB, IHC-P, IF (IHC-P), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), IHC-P (1:200-400), IF (IHC-P) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
842
Curated Selection
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