ARPC5 Recombinant Antibody

Product Specifications

Background

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079) . The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079) . In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947) . The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) .

Synonyms

Actin-related protein 2/3 complex subunit 5, Arp2/3 complex 16 kDa subunit, p16-ARC, ARPC5

Gene ID

10092

Swiss Prot

O15511

Host

Rabbit

Cross Reactivity

Human, Mouse

Immunogen

1-50/151

Target

ARPC5

Clonality

Recombinant

Isotype

IgG

Conjugation

Unconjugated

Source

Recombinant human p16 ARC around N-terminus

Applications

WB, FCM, IHC-P, IF (ICC), IHC

Purification

Purified by Protein A.

Concentration

1µg/µl

Dilution

WB (1:300-5000), FCM (1:20-100), IHC-P (1:200-400), IF (ICC) (1:50-200), IHC ()

Buffer

0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol

Modification

Unmodified

Storage Conditions

Store at -20°C for 12 months.

Gene ID URL

10092

Predicted Cross Reactivity

Rat

Available Sizes

Curated Selection

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