Phospho-Histone H3 (S10) Recombinant Antibody
Product Specifications
Background
Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
Synonyms
H3 3 like sequence MH921; H3 3A; H3 a; H3 b; H3 c; H3 d; H3 f; H3 h; H3 histone family member E pseudogene; H3 i; H3 j; H3 k; H3 l; H33_HUMAN; H3F3; H3f3b; Histone H3 3 pseudogene; Histone H3.3
Swiss Prot
P68431; P84243
Modification Site
Ser10
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
Phospho-Histone H3 (S10)
Clonality
Monoclonal
Isotype
IgG
Clone
2F6
Conjugation
Unconjugated
Source
Synthetic phospho-peptide corresponding surrounding Ser10 of human Histone H3
Applications
IHC-P, IHC-F, IF
Purification
Purified by Protein A.
Concentration
Lot Dependent
Dilution
IHC-P (1:200-400), IHC-F (1:100-500), IF ()
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C for 12 months.
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