Smad2 Recombinant Antibody

Product Specifications

Background

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Synonyms

JV18; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; Mad-related protein 2; SMAD family member 2; SMAD 2; Smad2

Gene ID

4087

Swiss Prot

Q15796

Host

Rabbit

Cross Reactivity

Human, Mouse, Rat

Target

Smad2

Clonality

Recombinant

Isotype

IgG

Conjugation

Unconjugated

Source

Recombinant human Smad2 protein, around N-terminal 1-200aa.

Applications

WB, IHC-P, IHC-F, IF, Flow-Cyt, ICC/IF

Purification

Purified by Protein A.

Concentration

Lot dependent

Dilution

WB (1:300-5000), IHC-P (1:200-400), IHC-F (1:100-500), IF (), Flow-Cyt (1ug/Test), ICC/IF (1:50-100)

Buffer

0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol

Modification

Unmodified

Storage Conditions

Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Gene ID URL

4087

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

ABC-KD5779 1 Vial

Human FUT5 knockdown cell line

Ask

View Details

AMM11933V 100 µL

Lipoprotein lipase (LPL) Mouse Monoclonal Antibody [Clone ID: LBI4H3]

Ask

View Details

GTR15228908 1 Vial

Lentiviral mouse Atp6v1c1 shRNA (UAS) - Lentiviral mouseAtp6v1c1 shRNA (UAS, GFP) (25)

Ask

View Details

53143121 3x 1.0µg DNA

ATQL4 CRISPRa sgRNA lentivector (set of three targets)(Human)

Ask

View Details

MBS1417616-01 0.02 mg (E-Coli)

Recombinant Burkholderia ambifaria NADH-quinone oxidoreductase subunit I (nuoI)

Ask

View Details

MBS1417616-02 0.1 mg (E-Coli)

Recombinant Burkholderia ambifaria NADH-quinone oxidoreductase subunit I (nuoI)

Ask

View Details