STAT3 (Tyr705) Monoclonal Antibody
Product Specifications
Background
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6) -responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity) .
Synonyms
APRF; HIES; ADMIO; Signal transducer and activator of transcription 3; Acute-phase response factor; STAT3
Gene ID
6774
Swiss Prot
P40763
Modification Site
Tyr705
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
STAT3 (Tyr705)
Clonality
Monoclonal
Isotype
IgG
Clone
4C2
Conjugation
Unconjugated
Source
Synthetic peptide derived from human STAT3 (Tyr705), around 700-750aa (phospho T705) .
Applications
WB, IHC-P, IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (WB (1:1000-2000) ), IHC-P (ICC (1:50-200) ), IF (ICC) (IHC (1:50-200) )
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
6774
Curated Selection
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