14-3-3 sigma Monoclonal Antibody, HRP Conjugated
Product Specifications
Background
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.1 Publication p53-regulated inhibitor of G2/M progression.
Synonyms
14-3-3 protein sigma; SFN; Epithelial cell marker protein 1; Stratifin; HME1
Gene ID
2810
Swiss Prot
P31947
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
14-3-3 sigma
Clonality
Monoclonal
Isotype
IgG
Clone
2E12
Conjugation
HRP
Source
Recombinant human 14-3-3 sigma protein, full length.
Applications
IHC-P, IHC-F
Purification
Purified by Protein A.
Concentration
Lot Dependent
Dilution
IHC-P (1:200-400), IHC-F (1:100-500)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
2810
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