B7-H3/CD276 Monoclonal Antibody
Product Specifications
Background
May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
Synonyms
B7H3; 4Ig B7 H3; 4Ig-B7-H3; AU016588; B7 H3; B7 homolog 3; B7-H3; B7H3; B7RP-2; CD_antigen=CD276; CD276; CD276 antigen; CD276 molecule; CD276_HUMAN; Costimulatory molecule; PSEC0249; UNQ309/PRO352.
Gene ID
80381
Swiss Prot
Q5ZPR3
Cellular Locus
Cell membrane
Host
Mouse
Target
B7-H3/CD276
Clonality
Monoclonal
Clone
F6D12
Conjugation
Unconjugated
Source
Recombinant human CD276.
Applications
WB, IHC-P, IHC-F, IF
Concentration
0.5µg/µl
Dilution
WB (WB=1:500-2000), IHC-P (IHC-P=1:100-400), IHC-F (IHC-F=1:100-400), IF (IF=1:100-500)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
80381
Predicted Cross Reactivity
Human
Curated Selection
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