MBD2 Monoclonal Antibody
Product Specifications
Background
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.
Synonyms
Demethylase; DMTase; MBD 2; MBD2_HUMAN; MBD2a; Methyl CpG binding domain protein 2; Methyl CpG binding protein MBD2; Methyl-CpG-binding domain protein 2; Methyl-CpG-binding protein MBD2; NY CO 41.
Gene ID
8932
Swiss Prot
Q9UBB5
Cellular Locus
Nucleus
Host
Mouse
Target
MBD2
Clonality
Monoclonal
Clone
G7R2
Conjugation
Unconjugated
Source
Recombinant human MBD2 between 10-228 amino acids.
Applications
WB, IHC-P, IHC-F, IF
Concentration
0.5µg/µl
Dilution
WB (WB=1:500-4000), IHC-P (IHC-P=1:25), IHC-F (IHC-F=1:25), IF (IF=1:25)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
8932
Predicted Cross Reactivity
Human
Curated Selection
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