KANK1 Monoclonal Antibody
Product Specifications
Background
Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.
Synonyms
ANKRD 15; Ankyrin repeat domain 15; Ankyrin repeat domain containing protein 15; Ankyrin repeat domain-containing protein 15; DKFZp451G231; KANK; KANK1_HUMAN; KIAA0172; Kidney ankyrin repeat containing protein; Kidney ankyrin repeat-containing protein; KN motif and ankyrin repeat domain-containing protein 1; MGC43128.
Gene ID
23189
Swiss Prot
Q14678
Cellular Locus
Cytoplasm, Nucleus
Host
Mouse
Target
KANK1
Clonality
Monoclonal
Clone
Y6S1
Conjugation
Unconjugated
Source
Recombinant human KANK1.
Applications
WB, IHC-P, IHC-F, IF
Concentration
0.5µg/µl
Dilution
WB (WB=1:500-2000), IHC-P (IHC-P=1:25), IHC-F (IHC-F=1:25), IF (IF=1:100-500)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
23189
Predicted Cross Reactivity
Human
Curated Selection
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