SP1 Monoclonal Antibody
Product Specifications
Background
Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation) . Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression.
Synonyms
Sp1 transcription factor isoform a; TSFP1; TSFP 1; Specificity protein 1; Transcription factor Sp1; SP1_HUMAN.
Gene ID
6667
Swiss Prot
P08047
Cellular Locus
Cytoplasm, Nucleus
Host
Mouse
Target
SP1
Clonality
Monoclonal
Clone
Y5R2
Conjugation
Unconjugated
Source
Recombinant human SP1.
Applications
WB, IHC-P, IHC-F, IF, Flow-Cyt, ICC/IF
Concentration
0.5µg/µl
Dilution
WB (WB=1:500-1000), IHC-P (IHC-P=1:100-500), IHC-F (IHC-F=1:100-500), IF (IF=1:100-500), Flow-Cyt (Flow-Cyt=1:25), ICC/IF (ICC/IF=1:100-500)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
6667
Predicted Cross Reactivity
Human
Curated Selection
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