APEX1 (15C2) Monoclonal Antibody
Product Specifications
Background
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]
Synonyms
APE; APX; APE1; APEN; APEX; HAP1; REF1; DNA- (apurinic or apyrimidinic site) lyase; APEX nuclease; Apurinic-apyrimidinic endonuclease 1; AP endonuclease 1; APE-1; REF-1; Redox factor-1; APEX1
Gene ID
328
Swiss Prot
P27695
Host
Mouse
Cross Reactivity
Human, Rat
Target
APEX1
Clonality
Monoclonal
Isotype
IgG1
Clone
15C2
Conjugation
Unconjugated
Source
This APEX1 antibody is generated from a mouse immunized with a recombinant protein of human APEX1.
Applications
WB, IHC-P
Purification
Purified by Protein G.
Concentration
0.5µg/µl
Dilution
WB (1:300-5000), IHC-P (1:200-400)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
328
Curated Selection
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