ITGB2 (4C1) Monoclonal Antibody

Product Specifications

Background

Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110) . Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992) . Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400) . Integrin alpha-L/beta-2 in assosiation with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590) .

Synonyms

LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1; Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; ITGB2

Gene ID

3689

Swiss Prot

P05107

Host

Mouse

Cross Reactivity

Human

Target

ITGB2

Clonality

Monoclonal

Isotype

IgG1

Clone

4C1

Conjugation

Unconjugated

Source

Purified His-tagged ITGB2 protein (Fragment) was used to produced this monoclonal antibody.

Applications

WB, IHC-P

Purification

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.