ATG4A (14C9) Monoclonal Antibody
Product Specifications
Background
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Synonyms
APG4A; AUTL2; Cysteine protease ATG4A; AUT-like 2 cysteine endopeptidase; Autophagin-2; Autophagy-related cysteine endopeptidase 2; Autophagy-related protein 4 homolog A; hAPG4A; ATG4A
Gene ID
115201
Swiss Prot
Q8WYN0
Host
Mouse
Cross Reactivity
Human
Target
ATG4A
Clonality
Monoclonal
Isotype
IgG2b
Clone
14C9
Conjugation
Unconjugated
Source
This ATG4A antibody is generated from a mouse immunized with a recombinant protein.
Applications
WB, IHC-P, IF (ICC), IF
Purification
Purified by Protein G.
Concentration
0.5µg/µl
Dilution
WB (1:300-5000), IHC-P (1:200-400), IF (ICC) (1:50-200), IF ()
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
115201
Curated Selection
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