PINK1 (8T5) Monoclonal Antibody
Product Specifications
Background
Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291) .
Synonyms
BRPK; PARK6; Serine/threonine-protein kinase PINK1, mitochondrial; PTEN-induced putative kinase protein 1; PINK1
Gene ID
65018
Swiss Prot
Q9BXM7
Host
Mouse
Cross Reactivity
Human
Target
PINK1
Clonality
Monoclonal
Isotype
IgG1
Clone
8T5
Conjugation
Unconjugated
Source
Recombinant PINK1 protein was used to produced this monoclonal antibody.
Applications
WB, IHC-P, IHC-F, IF, ICC/IF
Purification
Purified by Protein G.
Concentration
0.5µg/µl
Dilution
WB (WB=1:200-1000), IHC-P (IHC-P=1:100-500), IHC-F (IHC-F=1:50-100), IF (IF=1:25), ICC/IF (ICC/IF=1:25)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
65018
Curated Selection
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