SOX2 (7C4) Monoclonal Antibody

Product Specifications

Background

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation.

Synonyms

Transcription factor SOX-2; SOX2

Gene ID

6657

Swiss Prot

P48431

Cellular Locus

Nucleus

Host

Mouse

Cross Reactivity

Human

Target

SOX2

Clonality

Monoclonal

Isotype

IgG1

Clone

7C4

Conjugation

Unconjugated

Source

SOX2 recombinant protein

Applications

WB, FCM, IHC-P, IF (IHC-P), IF (ICC)

Purification

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.