PRKAA1 (7C6) Monoclonal Antibody
Product Specifications
Background
Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.
Synonyms
AMPK; AMPKa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; AMPK subunit alpha-1; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; Tau-protein kinase PRKAA1; PRKAA1; AMPK1
Gene ID
5562
Swiss Prot
Q13131
Host
Mouse
Cross Reactivity
Human
Target
PRKAA1
Clonality
Monoclonal
Isotype
IgG1
Clone
7C6
Conjugation
Unconjugated
Source
This PRKAA1 Monoclonal antibody was raised using purified His-tagged recombinant human PRKAA1.
Applications
WB, IHC-P
Purification
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
Concentration
0.5µg/µl
Dilution
WB (1:300-5000), IHC-P (1:200-400)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
5562
Curated Selection
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