ITA6 (9C5) Monoclonal Antibody

Product Specifications

Background

Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity) . ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778) . ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760) .

Synonyms

CD49f; VLA-6; ITGA6B; Integrin alpha-6; CD49 antigen-like family member F; ITGA6

Gene ID

3655

Swiss Prot

P23229

Host

Mouse

Cross Reactivity

Human

Target

ITA6

Clonality

Monoclonal

Isotype

IgG1

Clone

9C5

Conjugation

Unconjugated

Source

ITA6 recombinant protein is used to produce this monoclonal antibody.

Applications

WB, FCM, IHC-P, IF

Purification

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.