Human NCAM Ready-To-Use IHC Kit

Polysialic acid is a long homopolymer of sialic acid that is negatively charged and is attached to neural cell adhesion molecule (CD56) and serves as a regulator of NCAM function. PSA attachment to NCAM is associated with inhibited adhesion of neural cells. PSA-NCAM expression is highly regulated and corresponds to specific neural developmental windows in which neural precursors are migrating and during the process of axonal sprouting, guidance, and targeting. PSA-NCAM expression is prevalent during development of the brain, but in the adult becomes restricted to regions undergoing self-renewal or exhibiting plasticity such as the olfactory bulb, suprachiasmatic nucleus, hippocampus, hypothalamus, and specific spinal cord nuclei. PSA-NCAM is re-expressed during tumorigenesis and is also expressed on cell lines isolated from neuroblastomas and pheochromocytomas.

CD56; E-NCAM; MSK39; N-CAM; N-CAM-1; NCAM; NCAM-1; NCAM-C; NCAM1; NCAMC; CD56 antigen; Cell Adhesion Molecule Neural 1; N CAM 120; N CAM 180; NCAM 1; NCAM 120; NCAM 140.

PBS Buffer (powder) Antigen Retrieval Buffer Endogenous Peroxidase Blocking Buffer Blocking Buffer Primary Antibody (Human NCAM Recombinant Rabbit mAb) Secondary Antibody (Goat Anti-Rabbit IgG H&L / HRP) Chromogen Component A Chromogen Component B Counter Staining Reagent Differentiation Reagent Mounting Media Control slide (Human cerebellum) Datasheet

Storage and Stability: Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt.