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Human NFKB p65 Ready-To-Use IHC Kit

Product Specifications

Background

Nuclear factor kB p65 (NF-kB p65) is encoded by the RELA gene and is present on chromosome 11 in humans. NF-kB P65 is also known as RelA (v-rel avian reticuloendotheliosis viral oncogene homolog A) and belongs to the Rel family of proteins. It is one of the two subunits of NF-kB (Nuclear factor kappa-light-chain-enhancer of activated B cells) that heterodimerizes with the other subunits p50 or p52. However, binding of TNF alpha to its cognate receptor phosphorylates IKK which in turn phosphorylates I kB allowing proteasomal degradation of I kB. It specifically plays a key role in transcription of immunoglobulin k (kappa) gene in mature B-lymphoid cells.

Synonyms

P65, NF kB P65, NF-kB p65, NF-kB-p65, NFKBp65, NF-κBp65, NF-kBp65, Avian reticuloendotheliosis viral (v rel) oncogene homolog A, MGC131774, NFKB 3, NFKB3, RELA.

Cross Reactivity

Human

Target

Human NFKB

Sample Type

FFPE tissue

Components

PBS Buffer (powder) Antigen Retrieval Buffer Endogenous Peroxidase Blocking Buffer Blocking Buffer Primary Antibody (Human NFKB p65 Recombinant Rabbit mAb) Secondary Antibody (Goat Anti-Rabbit IgG H&L / HRP) Chromogen Component A Chromogen Component B Counter Staining Reagent Differentiation Reagent Mounting Media Control slide (Human breast cancer) Datasheet

Storage Conditions

Storage and Stability: Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt.

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