Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

(+) -Glaucarubinone

(+) -Glaucarubinone is a quassinoid compound and a potent activator protein-1 (AP-1) inhibitor with an EC50 value of 0.13 µM. (+) -Glaucarubinone has anti-tumor activity and can be used in the research of tumors such as hepatocellular carcinoma[1][2][3].

Product Specifications

CAS Number

[1259-86-5]

UNSPSC

12352005

Target

AP-1; Cadherin; MMP; p38 MAPK; PERK

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/plus-glaucarubinone.html

Purity

96.46

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@]3([H])[C@]45[C@@]([C@H]([C@H]([C@@]3(OC5)O)O)C)([H])[C@H](C(O[C@]4([H])C[C@@]1([H])C(C)=CC([C@H]2O)=O)=O)OC([C@@](C)(O)CC)=O

Molecular Formula

C25H34O10

Molecular Weight

494.53

References & Citations

[1]Diyabalanage T, et al. Nothospondin, a new AP-1 inhibitory quassinoid from the Cameroonian plant Nothospondias staudtii. Bioorg Med Chem Lett. 2011 Aug 1;21 (15) :4397-9.|[2]Grieco P A, et al. Synthetic studies on quassinoids: total synthesis of (-) -chaparrinone, (-) -glaucarubolone, and (+) -glaucarubinone. Journal of the American Chemical Society, 1993, 115 (14) : 6078-6093.|[3]Seo J, et al. Anti-Cancer Effects of Glaucarubinone in the Hepatocellular Carcinoma Cell Line Huh7 via Regulation of the Epithelial-To-Mesenchymal Transition-Associated Transcription Factor Twist1. Int J Mol Sci. 2021 Feb 8;22 (4) :1700.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Columbia Agar
MH144-5KG 5 Kg

Columbia Agar

Ask
View Details
Sheep IL-10 (Interleukin 10) ValidElisa Kit
EK343690 96 Well

Sheep IL-10 (Interleukin 10) ValidElisa Kit

Ask
View Details
Donkey FK506 Binding Protein 6 (FKBP6) ELISA Kit
MBS9920638 Inquire

Donkey FK506 Binding Protein 6 (FKBP6) ELISA Kit

Ask
View Details
HighQC™ Human Cord Blood CD34+ Stem Cell (Mixed Donor)
ABC-SC0082T 1 Vial

HighQC™ Human Cord Blood CD34+ Stem Cell (Mixed Donor)

Ask
View Details
Rabbit Polyclonal USP33 Antibody [HRP]
NB110-40693H 0.1 mL

Rabbit Polyclonal USP33 Antibody [HRP]

Ask
View Details