MZ1
Product Specifications
Background
MZ1 consists of JQ1 tethered to a ligand for the E3 ubiquitin ligase VHL and is a selective degrader of the BET bromodomain protein BRD4. It rapidly and potently induces reversible, long-lasting and unexpectedly selective degradation of BRD4 over BRD2 and BRD3.1 It exerts anticancer effects in acute myeloid leukemia by targeting c-Myc and ANP32B.2 An important tool for studying the effects of BRD4 degradation in cancer therapy.3
Conjugation
Unconjugated
Buffer
Pale-yellow solid
Storage Conditions
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K1487602 1.0 µg DNA
OR1I1 sgRNA CRISPR Lentivector (Human) (Target 1)
Sign In for Pricing
View Details 
397576 100 µg
TNFRSF13B (Tumor Necrosis Factor Receptor Superfamily Member 13B, Transmembrane Activator, CAML Interactor, CD267, TACI)
Sign In for Pricing
View Details MBS1488601-01 0.05 mg
Rabbit anti-human Potassium voltage-gated channel subfamily A member 1 polyclonal Antibody
Sign In for Pricing
View Details MBS1488601-02 0.1 mg
Rabbit anti-human Potassium voltage-gated channel subfamily A member 1 polyclonal Antibody
Sign In for Pricing
View Details MBS1488601-03 5x 0.1 mg
Rabbit anti-human Potassium voltage-gated channel subfamily A member 1 polyclonal Antibody
Sign In for Pricing
View Details 
SC204352 10 µg
Kallikrein 11 (KLK11) (NM_006853) Human 3' UTR Clone
Sign In for Pricing
View Details