SW033291

SW033291 is an inhibitor of 15-hydroxyprostaglandin dehydrogenase (IC50 = 1.5 nM) that increases prostaglandin E2 levels in bone marrow and other tissues by inhibiting in vivo degradation of PGE2.1 It accelerated neutrophil recovery, regeneration of platelets and red blood cells, and expanded the numbers of more primitive bone marrow SKL cells in bone marrow transplants. SW033291 also stimulated colon epithelial regeneration in a mouse model of ulcerative colitis. It increased bone formation in mice via PGE2 activation of EP4.2 SW033291 enhanced myogenic differentiation and myotube formation in repairing muscle defects in mice.3 It reduced the severity of pulmonary fibrotic lesions and extracellular matrix remodeling and improved pulmonary function in bleomycin-treated mice.4 It also prevented hepatic ischemia-reperfusion injury in mice.5 SW033291 mitigates oxidative damage, suppresses neuroinflammation, and restores blood-brain barrier integrity in mouse models of Alzheimer’s disease and traumatic brain injury.6 In addition to halting neurodegeneration, it also preserved cognitive function at levels indistinguishable from healthy controls.