(R) -GNE-140
Product Specifications
Background
(R) -GNE-140 is a potent (IC50’s: LDHA = 3 nM, LDHB = 5 nM, LDHC = 5 nM) pan-lactate dehydrogenase inhibitor.1 It significantly decreased lactate levels in vivo, although the effects were transient. GNE-140 suppressed lactic acid production, severely stunted glucose utilization, and impeded the anaerobic glycolytic pathway in MDA-MB-231 triple negative breast cancer cells.2
Conjugation
Unconjugated
Buffer
Off-white to pale orange solid
Storage Conditions
-20°C
Available Sizes
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