PF-06835919
Product Specifications
Background
PF-06835919 is a potent (IC50 = 10 nM KHK-C; 170 nM KHK-A) inhibitor of ketohexokinase (KHK), the first enzyme in the fructose metabolic cascade.1 It displayed high selectivity against other sugar kinases. PF-06835919 prevented hyperinsulinemia, hypertriglyceridemia, and hepatic steatosis in fructose-fed rats.2 The increased tumor proliferation effect of fructose in CaSki cells was inhibited by PF-06835919.3 An interesting new tool to study metabolic and fatty liver diseases.
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb2924378-01 20 µg
Recombinant Shigella dysenteriae serotype 1 Cardiolipin synthase (cls)
Sign In for Pricing
View Details orb2924378-02 100 µg
Recombinant Shigella dysenteriae serotype 1 Cardiolipin synthase (cls)
Sign In for Pricing
View Details 
127716-PE 100 µL
HAMP (Hepcidin, Liver-expressed Antimicrobial Peptide 1, LEAP-1, Putative Liver Tumor Regressor, PLTR, HEPC, LEAP1, UNQ487/PRO1003) (PE)
Sign In for Pricing
View Details