CR8 3HCl (R)
Product Specifications
Background
Second generation analog of roscovitine which inhibits cyclin-dependent kinases with increased potency, Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5, p25, and Cdk9/cyclin T, IC50s=0.09, 0.072, 0.041, 0.11 and 0.18 M respectively.1,2 Acts as a molecular glue degrader that depletes cyclin K.3 CR8 displays neuroprotective effects in various models including traumatic brain injury.4
Conjugation
Unconjugated
Buffer
White or off-white solid
Storage Conditions
-20°C
Available Sizes
Frequently Asked Questions
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