MLS-544460
Product Specifications
Background
MLS-544460 is an allosteric inhibitor of the Eya2 tyrosine phosphatase (IC50=4.1 uM) 1-2 which is ineffective against other tyrosine phosphatases including Eya3 and PTP1B. Treatment of patient-derived glioma stem cells induced loss of bipolar spindle formation along with G2/M cell cycle arrest. GSC proliferation was inhibited at concentrations 4 to 10-fold lower than normal brain cells.3 Treatment of Axolotls following amputation impairs limb regeneration indicating a role for Eya2 in vertebrate regeneration.4
Conjugation
Unconjugated
Buffer
Cream/off-white solid
Storage Conditions
-20°C
Available Sizes
Frequently Asked Questions
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