Arvanil

Arvanil is a non-pungent capsaicin analog with antinociceptive and anti-inflammatory effects in vivo.1 It is an agonist at TRPV1 as well as CB1 (Ki = 0.25 – 0.52 μM), but not CB2.2,3 Caused high mitochondrial calcium flow in hepatocellular carcinoma cells, ultimately leading to ferroptosis.4 It induced FADD-dependent apoptosis in lymphoid Jurkat T-cells.5 Neuroprotective in rat excitotoxicity model.6