Trichostatin A

Trichostatin A (58880-19-6) is a potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM) . Induces reversion of ras transformed cells to normal morphology. Trichostatin A induces dedifferentiation of primordial germ cells into embryonic germ cells. Cell permeable and active in vivo. Decreased global chromatin condensation increasing gene-editing efficiency 2-4X.4 Part of the CRISPY mix for increasing precise gene editing.5