Amlexanox

Improves obesity-related metabolic dysfunction in mouse models.1 Increases thermogenesis and weight loss, decreases steatosis and improves insulin sensitivity. Inhibits TANK-binding kinase 1 (TBK1) and IKK (IC50=1.2 M) .2 Clinically useful in the treatment of aphthus ulcers.3 Inhibits prostate tumor metastasis by targeting IKK/TBK1/NFB signaling.4