ODQ

A potent and selective inhibitor of soluble guanylyl cyclase (sGC), IC50 = 20 nM) .1 ODQ acts via competition with NO for the heme site of sGC where it binds irreversibly.2 ODQ does not inhibit NO-mediated macrophage toxicity, an activity that is unrelated to cGMP nor does it inhibit particulate GC.1 ODQ is an extremely useful tool to explore the involvement of the NO-cGMP pathway in cellular signaling and physiologic processes.3-5