Roxatidine

A novel histamine H2 receptor antagonist.1 Suppresses inflammatory responses via inhibition of NFB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages.2 Clinically useful agent for prevention and healing of gastric and duodenal ulcers and bleeding.3 Attenuates degradation of extracellular matrix in osteoarthritis models by inactivating the NFkB pathway.4