What is the catalog number for PF-543 HCl?

The catalog number for PF-543 HCl is bs-83079C.

What sizes are available for PF-543 HCl?

PF-543 HCl is available in the following size(s): 5 mg, 25 mg.

How many pack sizes does PF-543 HCl come in?

PF-543 HCl is available in 2 different pack sizes.

Is PF-543 HCl in stock?

PF-543 HCl is currently made to order / not held in immediate stock. Contact us for lead time.

PF-543 HCl

Product Specifications

Background

PF-543 (1706522-79-3) is a potent (IC50 = 2.0 nM) and selective (>100-fold over SphK2) reversible inhibitor of sphingosine kinase-1 (SphK1) .1 It induced autophagy in head and neck squamous cell carcinoma cells.2 PF-543 mitigated pulmonary fibrosis via reducing lung epithelial cell mitochondrial DNA damage and monocyte recruitment.3 It also alleviated sepsis-induced lung injury in an acute ethanol intoxication model in mice.4 PF-543 inhibited cell cycle and tumor growth in a xenograft model of non-small cell lung cancer.5