GSK872
Product Specifications
Background
GSK872 is a potent (IC50 = 1.8nM domain binding; IC50 = 1.3 nM kinase activity) and selective inhibitor of receptor interacting protein 3 (RIP3) .1 It is able to prevent necroptosis, virus-induced necrosis, and TLR3-induced necrosis.1,2 GSK872 can induce Caspase8-mediated apoptosis at higher concentrations (e.g.3 µM) .2
Conjugation
Unconjugated
Buffer
Off-white or pale yellow solid
Storage Conditions
-20°C
Available Sizes
Frequently Asked Questions
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