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SR-717

Product Specifications

Background

Cell permeable and exceptionally selective STING agonist (IC50 = 7.8 µM) . It displayed robust antitumor activity in B16.F10 melanoma and MC38 colorectal adenocarcinoma mouse models. SR-717 promoted the activation of CD8+ T, natural killer, and dendritic cells as well as promoting antigen cross-priming. It was able to induce PD-L1 expression in THP1 cells and in primary human PBMC’s.

Conjugation

Unconjugated

Buffer

Off-white solid

Storage Conditions

-20°C

Available Sizes

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