What is the catalog number for Defactinib?

The catalog number for Defactinib is bs-83039C.

What sizes are available for Defactinib?

Defactinib is available in the following size(s): 5 mg, 25 mg.

How many pack sizes does Defactinib come in?

Defactinib is available in 2 different pack sizes.

Is Defactinib in stock?

Defactinib is currently made to order / not held in immediate stock. Contact us for lead time.

Defactinib

Product Specifications

Background

Defactinib (1073154-85-4) is a potent inhibitor of FAK (IC50 = 0.6nM) and Pyk2 (IC50 = 0.6nM) .1 It is active in vivo (EC50 = 26nM) . FAK inhibition prevents tumor invasion and dissemination rather than tumor size reduction. Defactinib has been shown to preferentially target cancer stem cells in a mouse xenograft model of triple negative breast cancer.2 It is in multiple clinical trials for various cancers3 and in shows synergistic activity when used in combination with checkpoint immunotherapy 4-6.