Defactinib
Product Specifications
Background
Defactinib (1073154-85-4) is a potent inhibitor of FAK (IC50 = 0.6nM) and Pyk2 (IC50 = 0.6nM) .1 It is active in vivo (EC50 = 26nM) . FAK inhibition prevents tumor invasion and dissemination rather than tumor size reduction. Defactinib has been shown to preferentially target cancer stem cells in a mouse xenograft model of triple negative breast cancer.2 It is in multiple clinical trials for various cancers3 and in shows synergistic activity when used in combination with checkpoint immunotherapy 4-6.
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C
Available Sizes
Curated Selection
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