Quizartinib
Product Specifications
Background
Quizartinib is a potent and selective inhibitor of FLT3 (Kd = 1.6nM, IC50 = 0.56 nM MV4-11 cells) .1 It is in clinical trials for treatment of Acute Myelogenous Leukemia (AML) .2,3 Quizartinib priming resulted in prevention of myelosuppression in mice treated with 5-FU and Gemcitabine.4 Quizartinib showed significant reversal of ABCG2-mediated multidrug resistance (@ 3 µM) via antagonism of drug efflux function.5,6
Conjugation
Unconjugated
Buffer
Off-white to beige solid
Storage Conditions
-20°C
Available Sizes
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