What is the catalog number for Acalabrutinib?

The catalog number for Acalabrutinib is bs-83027C.

What sizes are available for Acalabrutinib?

Acalabrutinib is available in the following size(s): 5 mg, 25 mg.

How many pack sizes does Acalabrutinib come in?

Acalabrutinib is available in 2 different pack sizes.

Is Acalabrutinib in stock?

Acalabrutinib is currently made to order / not held in immediate stock. Contact us for lead time.

Acalabrutinib

Product Specifications

Background

Acalabrutinib (1420477-60-6) is a highly selective, potent (IC50 = 3nM), and irreversible inhibitor of Bruton’s tyrosine kinase (BTK) .1 Improved target selectivity (especially against TEC family kinases and EGFR) decreased the number of serious side effects observed with Ibrutinib.2 Acalabrutinib significantly inhibits BCR signaling, inhibits tumor proliferation, and reduces tumor burden.3 Clinically useful agent for treating B-cell cancers. BTK has also been shown to have a role in modulating the innate immune system, especially in dendritic cells and macrophages, suggesting a possible role in immunotherapy.4