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LDN-193189 HCl

Product Specifications

Background

LDN-193189 HCl is a potent and selective inhibitor of ALK2 (IC50 = 5 nM) and ALK3 (IC50 = 30 nM), thereby inhibiting SMAD1/5/8 phosphorylation.1 Only weak inhibition of ALK4, ALK5, and ALK7 is observed. Promotes neuronal differentiation of human pluripotent stem cells.2-3 LDN-193189 HCl has also been used to examine the role of osteogenesis in prostate tumor metastases in bone.4

Conjugation

Unconjugated

Buffer

Orange-yellow solid

Storage Conditions

-20°C

Available Sizes

Frequently Asked Questions

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