R428
Product Specifications
Background
R428 (1037624-75-1) is a potent and selective inhibitor of AXL kinase (IC50 = 1.4nM) .1 R428 has been shown to overcome chemotherapy resistance to various agents in multiple cancer models.2-5 AXL has been shown to suppress myeloid cell activation and function – combined AXL inhibition with R428 and PD-1 blockade showed potent synergistic antitumor effects.6,7
Conjugation
Unconjugated
Buffer
Yellow solid
Storage Conditions
-20°C
Available Sizes
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