ML365
Product Specifications
Background
ML365 is a potent (IC50 = 16 nM) and selective (62-fold selective over TASK-3) blocker of the two-pore domain potassium channel K2P3.1 (TASK-1) .1 It also less potently (IC50 = 4.07 µM) blocks the K2P6.1 (TWIK-2) channel resulting in blocking the ATP-induced NLRP3 inflammasome.2 ML365 improved the efficacy of Levetiracetam in chronically epileptic rats.3 It suppressed the release of TNF-α, IL-6, and IL-1ß in an LPS-induced inflammatory model via regulation of NF-kB signaling.4
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C
Product Datasheet
https://www.biossantibodies.com/datasheets/bs-82973C
Available Sizes
Curated Selection
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