VU0134992
Product Specifications
Background
VU0134992 is a blocker of the inward rectifier potassium channel Kir4.1 (IC50 = 970 nM) .1 It also inhibits Kir3.1/3.2, Kir3.1/3.4, and Kir4.2 with similar potency. VU0134992 induced diuresis, natriuresis, and kaliuresis in Sprague-Dawley rats suggesting therapeutic blood pressure lowering potential. It reduced polymyxin-induced nephrotoxicity in cell culture and mouse explant kidney tissue.2
Conjugation
Unconjugated
Buffer
Off-white/tan solid
Storage Conditions
-20°C
Available Sizes
Curated Selection
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