What is the catalog number for 7-Cl-O-Nec1?

The catalog number for 7-Cl-O-Nec1 is bs-82910C.

What sizes are available for 7-Cl-O-Nec1?

7-Cl-O-Nec1 is available in the following size(s): 5 mg, 25 mg.

How many pack sizes does 7-Cl-O-Nec1 come in?

7-Cl-O-Nec1 is available in 2 different pack sizes.

Is 7-Cl-O-Nec1 in stock?

7-Cl-O-Nec1 is currently made to order / not held in immediate stock. Contact us for lead time.

7-Cl-O-Nec1

Product Specifications

Background

Necrostatin-1 analogue with superior potency (IC50 = 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2 7-Cl-O-Nec-1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1) .3,4 7-Cl-O-Nec-1 showed higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC50 = 210 nM vs. EC50 = 490 nM), no non-specific cytotoxicity at high concentrations (100 µM) and reasonable pharmacokinetic characteristics when used in mice.2 7-Cl-O-Nec-1 is recommended for cellular and in vivo use over Necrostatin-1.5