N6022
Product Specifications
Background
N6022 is a potent and reversible inhibitor of S-nitrosoglutathione reductase (GSNOR) – IC50 = 20 nM1, 8 nM2. It demonstrated significant efficacy in a mouse models of ovalbumin-induced asthma, chronic obstructive pulmonary disease, and irritable bowel syndrome. N6022 was able to attenuate experimental autoimmune encephalomyelitis (an animal model of multiple sclerosis) via selective inhibition of pro-inflammatory CD4+ cells (TH1/TH17) while upregulating anti-inflammatory subsets of CD4+ cells (TH2/Treg) without causing lymphopenia.3
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C
Available Sizes
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