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SGC-iMLLT

Product Specifications

Background

Potent (IC50 = 260 nM) inhibitor of the YEATS domain of MLLT1/3.1 YEATS domain containing proteins bind acetyl and crotonyl marks on histone tails. Selective against the two other human YEATS domains YEATS2/4 and 48 bromodomains. YEATS containing MLL-ENL leukemic cells display increased sensitivity to SGC-iMLLT versus control AML cells.2

Conjugation

Unconjugated

Buffer

Off-white to beige solid

Storage Conditions

-20°C

Available Sizes

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