SP2509
Product Specifications
Background
Potent (IC50 = 13 nM) and reversible inhibitor of the histone demethylase LSD1 (KDM1A) .1 It is inactive against the closely related flavin enzymes MAO A, B as well as lactate dehydrogenase, several CYP’s and hERG. LSD1 regulates the balance between self-renewal and differentiation of stem cells and is highly expressed in various cancers.2-6 SP2509 promotes autophagy in neuroblastoma cells.7
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C
Available Sizes
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