ML210
Product Specifications
Background
ML210 is selectively synthetic lethal to HRAS expressing cells compared to isogenic non-HRAS cells (IC50 = 7.1 nM for BJeLR (expressing HRASg12v) cells vs IC50 = 272 nM for BJeH-LT (non-HRAS expressing) cells.1 ML210 is able to inhibit glutathione peroxidase 4 (GPX4), an important selenoenzyme that protects cells from ferroptosis caused by iron catalyzed formation of free radicals from lipid peroxides.2,3 Treatment of several treatment-resistant cancer cell lines exhibiting a high mesenchymal state with ML210 resulted in selective induction of ferroptosis.3
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
RT
Available Sizes
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