E7820
Product Specifications
Background
E7820 is an angiogenesis inhibitor that suppresses expression of integrins α2, α3, α5, and ß1.1 Broad-spectrum antitumor and antiangiogenic effects are mainly mediated via integrin α2 suppression.2 E7820 has been identified as a molecular glue that induces proteasomal degradation of the U2AF-related splicing factor CAPERα (RBM39) via CRL4DCAF15 mediated ubiquitination in human cancer cell lines.3,4 E7820 has also been shown to induce degradation of the aryl hydrocarbon receptor nuclear translator (ARNT), a protein essential in maintaining cellular homeostasis in response to environmental stress.5
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C
Product Datasheet
https://www.biossantibodies.com/datasheets/bs-82735C
Available Sizes
Curated Selection
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